VANDAM2 min read
VANDAM: Viewing a nucleotide sequence with DNA molecular priors
Contemporary Genomic Foundation Models (GFMs) rely on a DNA-as-a-string paradigm that employs masked token prediction objectives for pretraining. However, this abstraction does not explicitly model the biochemical, structural, and physical properties essential to biological function.
By Jeremy Levy, Ariel Larey, Yury Nahshan, Raizy Kellerman, Elay Dahan, Amit Bleiweiss, Guy Leib, Omri Nayshool, Dan Ofer, Tal Zinger, Dan Dominissini, Gideon Rechavi, Marissa Wirth, Simon Lee, Dung Hoang, Noam D. Beckmann, Shane O'Connell, Nicole Bussola, Alexander W. Charney, Yoli Shavit, Nati DanielarXiv - stat.ML
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Originally published by arXiv - stat.ML on Oct 2, 2026.
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